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At the α 2A -AR, a replacement of Asn for Lys at position 251 within the third intracellular loop results in a rare polymorphism, with a frequency of 0.4% and 5% in Caucasians and African Americans, respectively (Small et al., 2003)
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Cytotoxic cis-ruthenium(III) bis(amidine) complexes
Sensitivity = 10 nM
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