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A modern review by Pickart and Margolina ( International Journal of Molecular Sciences , 2018) synthesises transcriptomic data showing GHK modulates the expression of a large number of human genes across repair and protective pathways — the gene-regulation strand of GHK-Cu research
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Recent studies (187) have shown that overexpression of TREM2 effectively reduces the expression levels of NLRP3 and pro-caspase-1 proteins in rats, as well as the secretion of the inflammatory mediators IL-1β and IL-18, both in vivo and in vitro
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