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Most approved nasal formulations are liquid-based sprays that contain small-molecule drugs like sumatriptan to treat migraines and large molecules, including vitamin B12 and vasopressin [42]
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Considering the abovementioned findings, it is possible that natalizumab’s therapeutic properties in multiple sclerosis could depend, at least in part, on these intestinal effects, besides those seen in blood–brain barrier, integrins and lymphocyte trafficking
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