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Clinical characteristics of the 3 patients in whom HLA-DR–presented peptides were identified in synovectomy tissue samples Using epitope prediction tools from the Immune Epitope Database (IEDB), the 5 HLA-DR–presented peptides from ECM peptides identified in patients’ synovia were first analyzed for their predicted binding to HLA-DR molecules, and then other epitopes of the 3 ECM proteins were identified that were predicted to bind multiple, common HLA-DR molecules (Table 3)