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CYP1A1 – metabolism of estrogen, polyaromatic hydrocarbons, and more CYP1A2 – metabolism of caffeine, duloxetine, bupropion, aflatoxin B, and more CYP2A6 – metabolism of nicotine, coumarin, and more CYP2B6 – metabolism of ketamine, methadone, sertraline, and more CYP2C9 – metabolism of warfarin, rosuvastatin, celecoxib, and more CYP2C19 – metabolism of clopidogrel, some proton pump inhibitors, more CYP2D6 – metabolism of some antidepressants, antipsychotics, more CYP3A4 – metabolism of half of all prescription drugs CYP2E1 – metabolism of fatty acids, alcohol, and some anesthetics Phase II detoxification genes: UGT, GST, Nrf2 Phase II detoxification involves taking the metabolites of phase I and modifying them to be easily excreted through conjugation with sulfur, glutathione, glucuronic acid, amino acids, or methyl groups