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Consistently, SHIN1 mainly impaired STAT3 full activation in keratinocyte cultures following IL-22 and IFN-γ treatments, as well as STAT1 Ser727 phosphorylation induced by IFN-γ
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the constant domain of the light chain (C L which is ⁇ 110 amino acids in length) is aligned with and disulfide bonded to the first constant domain of the heavy chain (C H 1 which is 330 to 440 amino acids in length)
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