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BDNF binds to its specific receptor, tropomyosin receptor kinase, to activate the PI3K-Akt, Ras-Erk1/2, and phospholipase C γ1 / protein kinase C (PLCγ1/PKC) pathways, thus promoting the directional differentiation of NSCs, neuronal migration, as well as further axon and dendrite regeneration [168]
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