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Primary research: Gut inflammation, skin barrier function, general anti-inflammatory Mechanism: Inhibits NF-κB inflammatory signaling pathway activation Key advantage: Anti-inflammatory effects without immunosuppression — a critical distinction from corticosteroids Regulatory status: Not FDA-approved

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In the CY 2015 PFS final rule with comment period (79 FR 67606 through 67608), we modified this process whereby the public and interested parties may nominate PMVC for review by submitting the code with supporting documentation by February 10th of each year