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This mutant can still synthesize glutathione, but is not able to produce the inner membrane ABC-transporter CydDC that transports glutathione from the cytosol into the periplasm and hence suffers from reduced periplasmic glutathione levels [33,66,67]
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However, CuCl 2 and Cu(OAc) 2 significantly upregulated the extracellular protein expression of the three genes at concentrations (58 μM and 580 μM) without inhibiting the cell viability after 24 h
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