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In a cellular assay, cagrilintide was confirmed to be a non-selective agonist of the CTR and AMYRs across multiple assays of proximal and distal receptor signalling and receptor trafficking but only showed subtle difference in the kinetic response for activation of select G proteins as compared to sCT
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T 3 can also promote BAT thermogenesis effects [39], which are mainly mediated by T 3 in BAT stimulating the proliferation of brown adipose progenitor cells [65], increasing mitochondrial proliferation and Ucp1 expression, and increasing the mitochondrial β-oxidation capacity [66, 67]
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