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ROS-mediated mitochondrial defects contribute to the buildup of lipid droplets in glial cells, which are further peroxidized by ROS, initiating neurodegeneration in the retina (104)

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But even today, more than three decades after BPC-157 was first synthesized, a grand total of three human studies have been conducted, and none of them were the kind of large-scale human trial that’s typically part of the traditional drug-approval process