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These findings stress the importance of targeting mBzR/IMAC as a harbinger of more severe and permanent mitochondrial damage, which, through the ROS-induced ROS release mechanism, primes the opening of the PTP
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However, dynamic aspects of ferritin, such as transient conformational changes during iron loading/unloading or interactions with partner proteins (e.g., NCOA4, STEAP3), remain poorly visualized
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