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Oxidative stress is considered a common pathophysiological mechanism and it has been associated to many pathological conditions such as cancer [5,6], diabetes [7,8,9,10], cardiovascular [11,12] and neurodegenerative diseases [13,14]

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In recent years, novel therapies targeting p53, such as immunotherapy and gene therapy, have been developed, including vaccines, p53-specific antibodies, nanoparticles, siRNA delivery, and CRISPR–Cas9