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The frequency distribution of AEs was similar in both treatment groups: for ARA 290, 54 “mild,” 9 “moderate” and 1 “severe” categorizations were recorded, while for placebo, 61 “mild” and 5 “moderate” were noted

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If this beneficial effect and resolving adequately the anatomical imbalance in venous drainage would not occur, centrally, a harmful inability to drain venous blood adequately for a given cerebral blood inflow without raising venous pressures, suddenly goes to such venous and intracranial hypertension [60,61,62,63,64], as seen in the controls with the permanently occluded superior sagittal sinus