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Macromolecule Content Total Structure Weight: 46.5 kDa Atom Count: 3,393 Modeled Residue Count: 370 Deposited Residue Count: 416 Unique protein chains: 1 Experimental Data Method: X-RAY DIFFRACTION Resolution: 1.50 Å R-Value Free: 0.156 (Depositor), 0.140 (DCC) R-Value Work: 0.138 (Depositor), 0.139 (DCC) R-Value Observed: 0.138 (Depositor) Unit Cell : Software Package: Deposition Data Released Date: 2005-12-13 Deposition Author(s): Kavanagh, K.L., Johansson, C., Smee, C., Gileadi, O., von Delft, F., Weigelt, J., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC) Revision History (Full details and data files) Version 1.0: 2005-12-13 Type: Initial release Version 1.1: 2008-05-01 Changes: Version format compliance Version 1.2: 2011-07-13 Changes: Advisory, Version format compliance Version 1.3: 2015-04-29 Changes: Non-polymer description Version 1.4: 2023-08-30 Changes: Data collection, Database references, Derived calculations, Refinement description

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Additionally, microglia may contribute to the propagation of α-syn pathology by facilitating the intercellular spread of aggregates across brain regions (Zheng & Zhang, 2021)