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Key Points Bladder pain syndrome/interstitial cystitis (BPS/IC) is a disabling condition of growing incidence and considerable economic cost BPS/IC diagnosis and treatment are hampered by the lack of knowledge of basic urinary bladder function and pathophysiology However, the complex architecture of the urinary bladder provides various target structures for medicinal intervention Although several intravesical treatments are available, most are off-label Evidence from the literature supports the use of botulinum neurotoxin A injections, intravesical sodium hyaluronate instillation and instillation with dimethyl sulfoxide rather than glycosaminoglycan substitution or hyperbaric oxygen therapy The literature on intravesical therapies is scant and more high-quality randomized controlled trials are necessary to improve available data This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

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4 The researchers identify SLC33A1 as a transporter that exports oxidized glutathione, which helps maintain endoplasmic reticulum redox homeostasis (a stable chemical environment needed for accurate protein folding)