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Untreated Controls Preclinical injury models — % reduction in healing time Tendon Transection (Rat Achilles model)–50% Skin Wound Closure (Alkali burn model)–45% Muscle Crush Injury (Rat quadriceps)–40% Safety Data Safety Profile from Research What preclinical and early clinical studies report 📊 Preclinical Safety Summary LD50Not achieved Acute toxicityNone observed Chronic toxicityNone in 6-month studies Organ toxicityNone detected Human IV pilot (n=2)No adverse effects Cardiac/hepatic/renalNo effects detected ⚠️ Regulatory & Risk Considerations FDA statusUnapproved drug WADA statusBanned since 2022 (S0) Human trialsPhase 1 only Long-term effectsUnknown in humans Pro-angiogenic riskTheoretical — unstudied Australia/NZPrescription only 💡 No lethal dose was reached in preclinical toxicology studies

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