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DOX can also induce lipid peroxidation through DOX-Fe 2+ complexes in mitochondria, causing toxicity to the heart, and chelating agents that target Fe 2+ instead of Fe 3+ can effectively prevent DOX-induced ferroptosis (Tadokoro et al., 2020), which suggests that mitochondrial-dependent ferroptosis plays an important role in DOX-induced cardiotoxicity (DIC)
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