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Its distribution in macrophages under conditions of acute GC stimulation has not been previously evaluated, although certain levels of co-occupancy with GR have been reported in anti-inflammatory (“M2”) BMMΦ generated via long-term GC-driven polarization followed by a 3-h exposure to LPS 55

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Arbutin w/o/w nanoemulsions that were co-encapsulated with coumaric acid showed enhanced encapsulation efficiency, increased drug stability, sustained drug release, and improved skin delivery in comparison to the free drug (Wen et al., 2006a