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Presented by Zhao et al, the protein expression of PTEN was upregulated, while the expression level of MMP-9 was decreased in Ishikawa cells treated with kaempferol.197 In the PI3K/Akt signaling pathway, PTEN can convert phosphatidylinositol 3,4,5-triphosphate (PIP3) to phosphatidylinositol 4.5-bisphosphate (PIP2), thereby preventing the phosphorylation of Akt, and then inhibiting the activation of PI3K/Akt/mTOR signaling pathway (Figure 8).198 They also demonstrated that kaempferol exposure to Ishikawa cells inhibited cell migration and invasion by using scratch assay (wound healing) and perforation assay.197 Luteolin Luteolin (Figure 7) is a naturally occurring flavonoid that is widely distributed in flowers, vegetables, herbs, and spices.199,200 Cyclin D1 (CCND1), cyclin E1 (CCNE1), cyclin-dependent kinase 2 (CDK2), and cyclin-dependent kinase 4 (CDK4) are all cell cycle regulation-related proteins/genes, while CCND1 and CCNE1 are key molecules for G1 phase progression.201,202 Cyclin D1 can bind to either CDK4 or CDK6

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However, a comprehensive lipid profile that indicates a high risk of developing atherosclerosis is usually not apparent due to relatively low levels of triglycerides