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This leads to the decrease in catalase activity.52 Both animal and human studies have shown that catalase activity in BAL fluid is lower in patients with asthma as compared with that in healthy controls.53 The lower catalase activity is due to nitration and oxidation, which identifies oxidative inactivation as the mechanism of activity loss in vivo.53 Extracellular glutathione peroxidase is higher than normal in the lungs of patients with asthma
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