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Genitourinary Syndrome of Menopause Genitourinary syndrome of menopause encompasses the vaginal, vulvar, sexual, and urinary symptoms that result from estrogen deficiency

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These M2-polarized TAMs secrete vascular endothelial growth factor (VEGF), arginase-1, interleukin-10 (IL-10), and transforming growth factor-beta (TGF-β), which collectively support angiogenesis, suppress adaptive immunity, and facilitate tumor invasion and metastasis (164)