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Stopping Lyme Treatment Too Soon? Why Symptoms Return

doi: 10.1007/s12011-014-0033-5

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93 Although berberine has been studied and shown to have a high level of safety in human clinical trials, concerns about its long-term use have been raised on the basis of preclinical studies that suggest long-term berberine use, especially at high doses, may impair cellular metabolism in specific types of cells