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Further, atypical antipsychotics [50,51,52], NMDAR indirect agonists [53], NMDAR-glycine site agonists [54] studied in clinical trials for schizophrenia and large list of adjunctive agents with so far little advantage from different classes (i.e., antidepressants [55], psychostimulants [56], anxiolytics [57], anticonvulsants [58], muscarinic receptor agonists and peripehral antagonists [59], selective inhibitor or phosphodiesterase III [60], statins [61]) might also benefit from the studies of the NO-agents triple application and NO-specific therapy relation