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GCH1/BH 4 axis GCH1 (GTP cyclohydrolase 1) is responsible for catalyzing the conversion of GTP to BH4 (tetrahydrobiopterin), which is a potent antioxidant capable of effectively neutralizing intracellular free radicals and hindering lipid peroxidation, thereby impeding ferroptosis
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M., Kordower, J
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