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Infections with Granulibacter bethesdensis (a Gram-negative rod bacterium that causes chronic necrotizing lymphadenitis and sepsis) and Burkholderia gladioli (a Gram-negative rod bacterium which can cause osteomyelitis and sepsis) should prompt evaluation for CGD

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Beyond these XRCC1-dependent mechanisms, GCN5 and TADA2B may have broader roles in genome stability maintenance, which warrants further investigation