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Another potent multi-target inhibitor of c-MET, RON, VEGFR1, FGFR1/2/3, PDGFR, and other kinases is MK - 2461 (Merck), which reached phase I and II studies in patients with advanced solid tumors
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In vitro and xenograft model experiments have verified that miR-410 repression attenuates tumor growth and invasion by inhibiting MET and AKT signaling
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