glutathione synthesis mitochondria Altered mitochondrial fusion drives defensive in cells able to switch to glycolytic ATP production Mitochondrial dysfunction

glutathione synthesis mitochondria Altered mitochondrial fusion drives defensive in cells able to switch to glycolytic ATP production Mitochondrial dysfunction

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Apart from catalyzing the conjugation of carcinogenic electrophiles to GSH, the α-class GSTs (GSTA1-1 and GSTA2-2) attenuate LPO by catalyzing the GSH-dependent reduction of phospholipid hydroperoxides and fatty acid hydroperoxides through its Se-independent glutathione-peroxidase activity, thereby terminating the auto-catalytic chain of LPO reactions resulting in decreased formation of 4HNE (Zhao et al., 1999

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Abstract Type 2 diabetes mellitus (T2DM) is marked by chronic hyperglycemia, gradually worsening β-cell failure, and insulin resistance