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Triplication of chromosome 21, on which 21q22.1 gene encoding for SOD-1 is localized, leads to an increased SOD protein expression, and an imbalance in the ratio of SOD1 to CAT and GPX, which results the accumulation of H 2 O 2 and consequently damage to DS brain (Zana et al., 2007)

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Opioid-sensitive GABA inputs from rostromedial tegmental nucleus synapse onto midbrain dopamine neurons