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Similarly, mTORC1 also regulates purine biosynthesis by regulating the levels of MTHFD2 (mitochondrial tetrahydrofolate cycle enzyme methylenetetrahydrofolate dehydrogenase 2) via the transcription factor ATF4 (cyclic AMP-dependent transcription factor ATF-4) ( Role of mTORC1 in Energy Production and Metabolism Because all cellular biosynthetic activities are energy-consuming processes, mTORC1 also controls energy production and metabolism (Figure 1)
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