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314,316 This chronic low-grade inflammatory state is a feature of many diseases, including atherosclerosis, hypertension, obesity, type 2 diabetes, asthma, and neurodegenerative disorders
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The glycolysis regulator TEPP-46 can inhibit the pro-inflammatory effect of macrophages by obstructing the tetramerization of pyruvate kinase M2 (146) and simultaneously enhance the tolerance of macrophages to endotoxin (147)
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