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recent evidences, performed in transfected mouse neuroblastoma neuro2 cells, demonstrated that both wild type SOD1 (wt-SOD1) and SOD1 mutants are distributed into luminal structures of endoplasmic and Golgi apparatus (Urushitani et al., 2008)

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Driving adenylyl cyclase activation, cAMP elevation, and PKA-mediated phosphorylation of downstream targets that regulate GH secretory vesicle exocytosis